Clinical Trial: The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Brief Summary: The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults. The investigators hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce brain response in amygdala to sweet taste compared to sucrose.
Detailed Summary: We aim to identify neural factors that contribute to taste intensity perception in humans and to determine environmental mechanisms that contribute to variation in taste sensitivity. Significant controversy surrounds the possibility that consumption of artificial sweeteners (AFS) leads to weight gain. Given that the five FDA approved AFSs are found in thousands of foods (Yang 2010) this marks a clear and significant gap in knowledge. Our preliminary data demonstrate a 3-fold decrease in sweet taste sensitivity following consumption of a beverage sweetened with two packets of Splenda for just 10 days. These data provide strong evidence that repeated exposure to sucralose reduces perception of sweet taste intensity, most likely by down-regulation of the sweet taste receptor. Therefore, it is imperative that we gain a greater understanding of the physiological consequences of AFS, since alterations in sweet taste perception, metabolism and brain reward that occur in response to AFS exposure may promote weight gain.
Sponsor: Yale University
Current Primary Outcome: Ratings of taste sensitivity [ Time Frame: up to one week after intervention ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Ad libitum food intake [ Time Frame: up to one week after intervention ]amount of Mac&Cheese consumed
- brain response to taste stimuli [ Time Frame: up to one week after intervention ]BOLD response as measured by fMRI
Original Secondary Outcome: Same as current
Information By: Yale University
Dates:
Date Received: October 24, 2014
Date Started: January 2015
Date Completion: February 2019
Last Updated: October 9, 2016
Last Verified: October 2016