Clinical Trial: Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura

Brief Summary: Previous studies suggest that chronic idiopathic thrombocytopenic purpura is associated with Helicobacter pylori infection. The objective is to study the effect of Helicobacter pylori eradication on platelet count.

Detailed Summary: Children with chronic idiopathic thrombocytopenic purpura who have Helicobacter pylori infection are enrolled. Helicobacter pylori infection is diagnosed by urea breath test. Patients who have Helicobacter pylori infection will be randomized into 2 groups: control and treatment groups. The treatment group will receive 2 antibiotics and proton-pump inhibitors for 14 days for eradication of infection. Repeated urea breath test at week 6-8 after treatment. Blood tests for platelet count will be performed every month for 6 months in both groups. Platelet count at 6 months in both group will be compared.Blood for platelet antibody will be performed at 3 and 6 months. Control group will receive treatment for Helicobacter pylori at the end of the study.
Sponsor: Mahidol University

Current Primary Outcome: platelet count [ Time Frame: 6 months ]

Original Primary Outcome: Platelet count after treatment of Helicobacter pylori infection, compared with control group (no treatment of Helicobacter pylori [ Time Frame: 6 months ]

Current Secondary Outcome:

  • platelet antibody after treatment of Helicobacter pylori infection, compared with control group (no treatment of Helicobacter pylori) [ Time Frame: 6 months ]
  • platelet count [ Time Frame: 6 months ]


Original Secondary Outcome: platelet antibody after treatment of Helicobacter pylori infection, compared with control group (no treatment of Helicobacter pylori) [ Time Frame: 6 months ]

Information By: Mahidol University

Dates:
Date Received: April 27, 2007
Date Started: March 2006
Date Completion:
Last Updated: May 1, 2013
Last Verified: September 2008