Clinical Trial: Neurophysiologic Correlates of Hypersomnia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Neurophysiologic Correlates of Hypersomnia: a High Density EEG Investigation

Brief Summary: The goal of this project is to examine the neurophysiology of hypersomnia during sleep and wakefulness, to identify biomarkers for excessive sleepiness in neuropsychiatric disorders, and pilot acoustical slow wave induction during sleep in patients with hypersomnolence, to determine if this decreases daytime sleepiness in these patients. The primary study hypotheses are that individuals with hypersomnolence will have reduced slow wave activity (SWA) during sleep and increased waking theta/alpha activity during wake in specific brain regions. A secondary hypothesis is that acoustical slow wave induction in hypersomnolent patients will increase SWA during sleep, reduce theta/alpha activity during wake, and improve subjective sleepiness.

Detailed Summary:
Sponsor: University of Wisconsin, Madison

Current Primary Outcome: Nocturnal Slow Wave Activity [ Time Frame: Individual nights of sleep recorded within an average of 4 weeks of enrollment ]

EEG recordings during sleep will be analyzed to assess slow wave activity in the 1-4.5Hz range.


Original Primary Outcome: Same as current

Current Secondary Outcome: Waking theta/alpha activity [ Time Frame: Individual days of waking EEG will be recorded within an average of 4 weeks of enrollment ]

Waking EEG activity across the 1-12Hz range will be analyzed.


Original Secondary Outcome: Same as current

Information By: University of Wisconsin, Madison

Dates:
Date Received: October 24, 2012
Date Started: November 2012
Date Completion: June 2018
Last Updated: May 12, 2016
Last Verified: May 2016