Clinical Trial: Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus
Brief Summary:
It is well known that 'globus sensation in throat' is caused by the chronic irritation and inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and chronic postnasal drip.
Xerostomia and pharyngoxerosis due to salivary hypofunction also proved to induce the mucosal change of the oral cavity and pharynx.
However, no previous studies have documented the prevalence of salivary hypofunction in patients with globus pharyngeus.
Through this clinical investigation, we hypothesized that the salivary hypofunction might be one of the leading cause of globus pharyngeus.
Detailed Summary:
Subjects: patients with symptoms of globus pharyngeus
Globus symptom scoring: 0(mild) to 5(severe)
Subjective symptom analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Subjective physical finding analysis by "Standard Table for Xerostomia and Pharyngoxerosis"
Objective analysis of Salivary function by 99m-Tc Salivary scintigraphy
--> Define the prevalence of salivary hypofunction in patients with globus pharyngeus (Primary end point)
Subsequent analysis (Secondary end point)
- Group 1: Globus patients with objective salivary hypofunction
- Group 2: Globus patients with normal salivary function
Intervention: Active management for xerostomia (Moisturizing, Gargling, Humidification, Massage of salivary gland, Stimulant of salivary secretion, Artificial saliva)
Evaluation of the change of globus symptoms after active management of xerostomia between the Group 1 and Group 2 (at 1 months, at 3 months after the initiation of intervention)
Sponsor: Samsung Medical Center
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Samsung Medical Center
Dates:
Date Received: September 27, 2006
Date Started: February 2006
Date Completion:
Last Updated: July 27, 2010
Last Verified: July 2010
