Clinical Trial: Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During

Brief Summary: The aim of this study is to distinguish possible differences in frequency of delirium after Volatile Induction and Maintenance of Anesthesia and Total Intravenous Anesthesia in case of undeliberate cerebral desaturation during non-cardiac surgery.

Detailed Summary: The aim of the present study is to investigate whether in non-cardiac surgery the frequency of POD after intraoperative undeliberate cerebral saturation could be modulated by the choice of the anesthetic strategy (Volatile Induction and Maintenance of Anesthesia [VIMA] and Total Intravenous Anesthesia [TIVA]). Based on our previous data we hypothesized that incidence of POD would be lower with VIMA compared to TIVA.
Sponsor: Negovsky Reanimatology Research Institute

Current Primary Outcome:

  • Regional Cerebral Oxygenation (rSO2) [ Time Frame: Continued the entire surgery ]
  • Peripheral tissue oxygen saturation (SpO2) [ Time Frame: Continued the entire surgery ]
  • Non-invasive blood pressure (NIBP) [ Time Frame: Continued the entire surgery ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Number of Incidences of postoperative delirium (POD) [ Time Frame: Baseline, 24h and 48h after surgery ]
    Applying the Confusion Assessment Method for the ICU (CAM-ICU)
  • Plasma concentration of S100b protein [ Time Frame: Baseline, 24h and 48h after surgery ]
    S100b protein is the neuronal injury marker


Original Secondary Outcome: Same as current

Information By: Negovsky Reanimatology Research Institute

Dates:
Date Received: May 6, 2014
Date Started: May 2014
Date Completion: June 2015
Last Updated: May 6, 2014
Last Verified: May 2014