Clinical Trial: The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane

Brief Summary: the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .

Detailed Summary: the purpose of this study:(1) to investigate the incidence of preoperative cerebral oxygenation abnormity (SjvO2 <55%) and its relationship with intraoperative cerebral desaturation and POCD. (2) To investigate the change of intraoperative cerebral oxygen supply and demand balance and the incidence of cerebral desaturation in patients with abnormal preoperative cerebral oxygenation during sevoflurane anesthesia. (3)To investigate the incidence of early POCD in patients with abnormal preoperative cerebral oxygenation during sevoflurane and propofol anesthesia.
Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Current Primary Outcome: the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia [ Time Frame: baseline ,every hour in the operation period,after extubation ]

SjvO2 were measured before anesthesia, after intubation, every hour during operation, after extubation by jugular vein blood and atrial blood gas analysis.The incidence of intraoperative cerebral desaturation was recorded when SjvO2<50%.


Original Primary Outcome: the change in jugular vein bulb oxygen saturation between propofol and sevoflurane general anesthesia [ Time Frame: baseline ,every hour in the operation period,after extubation ]

Current Secondary Outcome:

  • the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia [ Time Frame: 1-3days、5-7days after operation ]
    The incidence of early POCD was recorded. The MMSE score and the Montreal cognitive assessment (MoCA) score were recorded 1day before surgery, 1-3 day after surgery and 5-7 day after surgery. The POCD was defined as MMSE score illiterate group ≤ 17, primary and secondary school group ≤ 20, junior high school and above group ≤ 24，or the MoCA score decreased 20% with the baseline.
  • the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia [ Time Frame: before anesthesia, after extubation ,1day after operation ]
  • the Change in the Level of Serum s-100β Between Propofol and Sevoflurane Anesthesia [ Time Frame: before anesthesia,after extubation,1 day after operation ]


Original Secondary Outcome:

  • the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia [ Time Frame: 7days after operation ]
  • the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia [ Time Frame: before anesthesia, after extubation ,1day after operation ]
  • the Change in the Level of Serum s-100β Between Propofol and Sevoflurane Anesthesia [ Time Frame: before anesthesia,after extubation,1 day after operation ]


Information By: First Affiliated Hospital, Sun Yat-Sen University

Dates:
Date Received: December 18, 2012
Date Started: December 2012
Date Completion:
Last Updated: August 18, 2015
Last Verified: August 2015