Clinical Trial: Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Brief Summary: The primary objective of this research is to measure neurochemicals in the activated human brain during both normoxia (normal oxygen availability) and induced mild hypoxia (reduced oxygen availability).

Detailed Summary: The goal is to determine the effect of mild hypoxia on human brain energy metabolism of healthy young adult subjects. For this purpose, the Investigator will utilize non-invasive imaging modalities based on functional magnetic resonance imaging (fMRI) and spectroscopy (fMRS), while subjects are exposed to well-controlled gas mixtures that resembles conditions of either normoxia or mild hypoxia. Identifying the impact of mild hypoxia on functional brain energy metabolism in the healthy human brain is a crucial step for generating hypotheses in multiple patient populations that experience mild hypoxia as consequence of their pathological condition, such as in sleep apnea and traumatic brain injury. The Investigator hypothesize that the energetic demands of neuronal activation as revealed by fMRS will not be affected by mild hypoxia, despite an altered hemodynamic response observed with fMRI.
Sponsor: University of Minnesota - Clinical and Translational Science Institute

Current Primary Outcome: Concentration of brain metabolites measured by functional MRS [ Time Frame: Baseline ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Brain activity measured by functional MRI [ Time Frame: Baseline ]

Original Secondary Outcome: Same as current

Information By: University of Minnesota - Clinical and Translational Science Institute

Dates:
Date Received: June 23, 2015
Date Started: March 2016
Date Completion: December 2017
Last Updated: January 20, 2017
Last Verified: January 2017