Clinical Trial: Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Is Variation of Plasmatic Protein Concentration During Continuous Renal Replacement Therapy Predictive of Hypovolemia in Intensive Care Unit?

Brief Summary: The aim of the study is to analyze if blood protein concentration variation during CRRT with fluid removal can predict a decrease of 15 % of cardiac index in ICU patients. Blood protein concentration, clinical data describing hemodynamic status (providing data from PICCO2 monitoring), including preload dependence evaluation with passive leg raising, are collected at different times: before initiation of fluid removal, and after the first episode of hypotension or one hour after initiation of fluid removal.

Detailed Summary:
Sponsor: Hopital Louis Pradel

Current Primary Outcome: plasmatic protein concentration variation [ Time Frame: 1 hour ]

Two sample of plasmatic protein before and after a fluid rempoval will be performed. The variation of the protein concentration (computed as the difference between final and baseline value divided by the baseline value expressed in %) will be the index test to diagnose a decrease of cardiac output of more than 15 % due to the fluid removal.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Plasmatic protein concentration in patient with preload dependence before fluid removal [ Time Frame: 1 hour ]
    hemoconcentration will be evaluated in the subgroup of preload dependent patients
  • Central venous pressure [ Time Frame: 1 hour ]
    CVP will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
  • GEDV, [ Time Frame: 1 hour ]
    GEDV, calculated with transpulmonary thermodilution will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
  • EVLW, [ Time Frame: 1 hour ]
    EVLW, calculated with transpulmonary thermodilution will be tested to evaluate the diagnostic ability to diagnose a reduction of cardiac output due the fluid removal
  • hemoconcentration evaluated with hemoglobin variation [ Time Frame: 1 hour ]
    hemoconcentration evaluated with hemoglobin variation will be tested to evaluate the diagnostic abilty to diagnose a reduction of cardiac output due the fluid removal


Original Secondary Outcome: Same as current

Information By: Hopital Louis Pradel

Dates:
Date Received: December 26, 2016
Date Started: December 2016
Date Completion: December 2017
Last Updated: May 4, 2017
Last Verified: May 2017