Clinical Trial: Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests in Patients Undergoing Endoscopic Endonasal Transsphenoidal Surgery of Pituitary Glan

Brief Summary: This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Detailed Summary: Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.
Sponsor: Istanbul University

Current Primary Outcome: Change from baseline FEV1%predicted (no unit) [ Time Frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour ]

FEV1 is measured with spirolab III colour liquid-crystal-display medical spirometer. FEV1%predicted is calculated with age, sex, height and weight input by the same equipment.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change from baseline FVC%predicted (no unit) [ Time Frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour ]
    FVC is measured with spirolab III colour liquid-crystal-display medical spirometer. FVC%predicted is calculated with age, sex, height and weight input by the same equipment.
  • Change from baseline FEV1/FVC ratio (no units) [ Time Frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour ]
    FEV1/FVC ratio is calculated by spirolab III colour liquid-crystal-display medical spirometer based on age, sex, height and weight.
  • Change from baseline PaO2 (mmHg) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    PaO2 is a component of arterial blood gas analysis done with Cobas B221.
  • Change from baseline PaCO2 (mmHg) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    PaCO2 is a component of arterial blood gas analysis done with Cobas B221.
  • Change from baseline pH [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    pH is a component of arterial blood gas analysis done with Cobas B221
  • Change from baseline SaO2 (%) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    SaO2 is a component of arterial blood gas analysis done with Cobas B221
  • Change from baseline BE (mmol/L) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    BE is a component of arterial blood gas analysis done with Cobas B221
  • Change from baseline HCO3 (mmol/L) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    HCO3 is a component of arterial blood gas analysis done with Cobas B221
  • Change from baseline PaO2/FiO2 ratio (no units) [ Time Frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour ]
    PaO2/FiO2 ratio is calculated by investigators


Original Secondary Outcome: Same as current

Information By: Istanbul University

Dates:
Date Received: February 23, 2016
Date Started: October 2015
Date Completion: February 2017
Last Updated: March 10, 2016
Last Verified: March 2016