Clinical Trial: Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Comparative Low and High Dose of Dexmedethomidine Can Stabilize Hemodynamics and Blood Loss in Pituitary Tumor Removal by Transphenoid Approach

Brief Summary: Transnasal transsphenoidal (TNTS) resection of pituitary tumors involves wide fluctuation in hemodynamic parameter and causes hypertension and tachycardia due to intense noxious stimuli during various stages of surgery. None of routinely used anesthetic agents effectively blunts the undesirable hemodynamic responses, and therefore usually there is a need to use increased doses of anesthetic agents. Dexmedetomidine (DEX) an α-2 adrenergic receptor agonist, because its sympatholytic and antinociceptive properties may ensure optimal intraoperative hemodynamic stability during critical moments of surgical manipulation. In addition, DEX reduced the anesthetic requirement with rapid recovery at the end of surgery. The main aim of the study was to evaluate the effect of DEX on perioperative hemodynamics, anesthetic requirements

Detailed Summary: DEX as an anesthetic adjuvant improved hemodynamic stability and decreased anesthetic requirements in patients undergoing TNTS resection of pituitary tumor. In addition, DEX provided better surgical field exposure conditions and early recovery from anesthesia
Sponsor: Mahidol University

Current Primary Outcome: Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach [ Time Frame: 24 hours ]

Low dose is 0.2microgram/kg/hr High dose is 0.5 microgram/kg/hr what is the dose proper and hemodynamic changes. Hemodynamic change means BP is lower than 20% of baseline more than 10minute


Original Primary Outcome: Same as current

Current Secondary Outcome: Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor [ Time Frame: 24 hours ]

Low dose is 0.2microgram/kg/hr High dose is 0.5 microgram/kg/hr how much dose blood loss


Original Secondary Outcome: Same as current

Information By: Mahidol University

Dates:
Date Received: July 18, 2016
Date Started: May 2016
Date Completion: June 2017
Last Updated: April 24, 2017
Last Verified: April 2017