Clinical Trial: The Cardiovascular Changes Associated With Septal Local Anaesthesia

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: An Observational Study of the Cardiovascular Response to Infiltration of Local Anaesthetic Into the Nasal Septum in Patients Undergoing Trans-sphenoidal Resection of a Pituitary Lesion

Brief Summary: The purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?

Detailed Summary:

People sometimes require surgery on their pituitary gland. This is a gland at the base of your brain which secretes hormones. At the Royal Hallamshire Hospital the investigators are currently conducting a study into the effects of local anaesthetic (a medicine which causes numbness) injection on patients undergoing this particular type of operation.

After patients are anaesthetised (asleep) but before surgery starts the surgeon injecst a local anaesthetic solution into the nose. This is routine practice and is done to provide pain relief afterwards and also to decrease the amount of bleeding during the operation to ensure that the surgeon has a good view.

The investigators have known for a long time that local anaesthetic affects the heart rate and blood pressure, however the investigators would like to describe exactly how, in much more detail.


Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust

Current Primary Outcome: Change in blood pressure after administration of local anaesthesia [ Time Frame: 5 minutes ]

Changes in mean arterial pressure from baseline after infiltration of local anaesthetic.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in heart rate after administration of local anaesthesia [ Time Frame: 5 minutes ]
    Changes in mean arterial pressure from baseline after infiltration of local anaesthetic.
  • Change in cardiac output after administration of local anaesthesia [ Time Frame: 5 minutes ]
    Changes in cardiac output from baseline after infiltration of local anaesthetic.
  • Change in systemic vascular resistance after administration of local anaesthesia [ Time Frame: 5 minutes ]
    Changes in systemic vascular resistance from baseline after infiltration of local anaesthetic.


Original Secondary Outcome: Same as current

Information By: Sheffield Teaching Hospitals NHS Foundation Trust

Dates:
Date Received: November 20, 2015
Date Started: November 2014
Date Completion:
Last Updated: April 28, 2017
Last Verified: April 2017