Clinical Trial: Phenylephrine for Spinal Induced Hypotension

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Up-down Determination of the ED90 of Phenylephrine for Spinal Induced Hypotension in Parturients Undergoing Cesarean Delivery

Brief Summary: This study is designed to determine the ED90 for a single dose of phenylephrine for the treatment of spinal induced hypotension in parturients presenting for an elective CD. The ED90 is the effective dose at which 90% of subjects will have a "positive" response to phenylephrine. The primary outcome measure is the ED90 for bolus phenylephrine. Secondary outcomes include the need for additional vasopressors, glycopyrolate to treat bradycardia, and the presence of hypertension following administration of phenylephrine.

Detailed Summary:
Sponsor: IWK Health Centre

Current Primary Outcome: The primary outcome measure is the ED90 for bolus phenylephrine. [ Time Frame: Intraoperative ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Secondary outcomes include the need for additional vasopressors, glycopyrolate to treat bradycardia, and the presence of hypertension following administration of phenylephrine. [ Time Frame: Intraoperative ]

Original Secondary Outcome: Same as current

Information By: IWK Health Centre

Dates:
Date Received: October 27, 2008
Date Started: January 2008
Date Completion:
Last Updated: May 22, 2013
Last Verified: May 2013