Clinical Trial: Hypoalbuminemia in Burn Patients

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Hypoalbuminemia in Burn Patients: Should we Care? - A Randomized Controlled Clinical Pilot Trial

Brief Summary: The purpose of this study is to determine whether 5% human albumin solution, given to correct hypoalbuminemia, could improve organ dysfunction in burn patients as assessed by a change in the SOFA score from baseline to day 7 (or before if the patient is discharged from the ICU or died).

Detailed Summary:

Each year approximately 2 million people are burned in the USA, from which 80,000 are hospitalized and 6,500 die. It is a well known fact that the two most important factors for mortality in burn patients are age and percent total body surface area burn (TBSA), which are unmodifiable findings.

A predictable inflammatory response takes place after a burn injury leading to profound changes in patient homeostasis. As a result, hypoalbuminemia is one of the common finding in severe burn patients. 21% of hospitalized adult patients are hypoalbuminemic on admission. After admission, worsening of existing hypoalbuminemia and development of de novo one are frequently seen.

Moreover, hypoalbuminemia, a potentially modifiable variable, has been strongly associated with poor clinical outcomes in critically ill patients and in burn patients.

Dynamic organ dysfunction scores have been introduced in critically ill patients few years ago in order to describe the evolution of patients on a daily basis. The Sequential Organ Failure Assessment (SOFA) score is now one of the most accepted score in critically ill patients and has been validated in general medico-surgical unit, as well as in trauma and cardiac surgery patients. It encompasses components assessing six organ functions. This score has also been shown to predict mortality in critically ill patients and in burn patients when used in a dynamic way.


Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Current Primary Outcome: Organ dysfunction as assessed by a change in the SOFA score from baseline to day 7 (or before if the patient is discharged from the ICU or died). [ Time Frame: Seven days ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • ICU and hospital mortality [ Time Frame: 1, 3 and 6 months ]
  • ICU and hospital length of stay [ Time Frame: 1, 3 and 6 months ]
  • Free days of mechanical ventilation [ Time Frame: Seven days ]
  • Caloric intake [ Time Frame: Seven days ]
  • Fluid balance [ Time Frame: Seven days ]
  • Incidence of infection [ Time Frame: Seven days ]
  • Time to complete coverage defined as the time between admission and last surgery for grafting [ Time Frame: 1, 3 and 6 months ]


Original Secondary Outcome: Same as current

Information By: Centre hospitalier de l'Université de Montréal (CHUM)

Dates:
Date Received: July 14, 2011
Date Started: September 2011
Date Completion: October 2015
Last Updated: September 16, 2011
Last Verified: September 2011