Clinical Trial: Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational
Official Title: Acid Base Balance of ICU Patients With Severe Hypoalbuminemia, Before and After an Albumin Infusion, Using Stewart Approach
Brief Summary: The primary purpose was to describe the acid base balance of ICU patients with severe hypoalbuminemia using Stewart's approach for acid base disorders, before and after an human albumin perfusion.
Detailed Summary:
Prospective study, for ICU patient with severe hypoalbuminemia < 20g/L, determining biological parameters from Stewart approach for acid base disorders (pH, SIDe, SIDa, SIG, Atot, PaCO2) before, and at 1hour, 2hours and 24 hours after a 200mL 20% human albumin perfusion (the consensus conference ANAES of 1995 recommands to correct hypoalbuminemia below 20g/L).
Clinical parameters (respiratory, haemodynamic, neurologic) were also collected at the same times.
Sponsor: University Hospital, Clermont-Ferrand
Current Primary Outcome: changes in pH and independent pH determinants using Stewart approach [ Time Frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- changes in neurologic parameters [ Time Frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. ]
- changes in hemodynamic parameters [ Time Frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. ]
- changes in respiratory parameters [ Time Frame: at 1 hour, 2 hours and 24 hours after a 200mL of 20% human albumin perfusion. ]
Original Secondary Outcome: Same as current
Information By: University Hospital, Clermont-Ferrand
Dates:
Date Received: September 12, 2014
Date Started: October 2013
Date Completion: November 2014
Last Updated: November 7, 2014
Last Verified: November 2014
