Clinical Trial: Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Pharmacogenetic and Pharmacokinetic Aspects of the Response to Chemotherapy Induction Using Docetaxel, Cisplatin and 5-Fluorouracile (TPF)in ORL Cancers

Brief Summary: The purpose of this study is to determine if there is a correlation between tumor response after 3 doses of chemotherapy by induction using Docetaxel, Cisplatine and 5-Fluorouracile for advanced stage epidermoid carcinomas of the upper aero digestive tract and the presence of one or a combination of 3 genetic polymorphisms and/or 5 intra-tumoral transcriptional modifications.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire de Nīmes

Current Primary Outcome: %change in tumor volume before and after chemotherapy (baseline versus 62 days) [ Time Frame: 62 days ]

Tumor volume is calculated according to Labadie et al 2000


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire de Nīmes

Dates:
Date Received: April 14, 2010
Date Started: April 2010
Date Completion:
Last Updated: March 25, 2015
Last Verified: March 2015