Clinical Trial: Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Characterisation of Neuropsychological and Motoric Performance in Patients With Hyponatremia
Brief Summary: The aim of this epidemiological study is to characterize the neuropsychological and motoric performance in patients with hyponatremia. Newer studies revealed an association between mild hyponatremia and unstable walking, frequency of falls and risk of a fracture, questioning the paradigm of an "asymptomatic" hyponatremia. Until now, there is no known detailed investigation and characterisation of the cognitive and motoric performance or limitation by this disorder. Therefore this study will investigate patients with hyponatremia on the basis of neuropsychological and neurological tests.
Detailed Summary:
Hyponatremia is the most common electrolyte disorder in outpatients and hospitalized patients. The prevalence of hospital-associated hyponatremia is estimated to be up to 40%. Especially mild to moderate hyponatremia (125-136 mmo/l) without apparent symptoms has seldomly been accurately assessed but rather seen as clinically irrelevant. Cognitive limitations, unstable gait and motoric disorders as well as depressive conditions were described in smaller studies and single case reports.
In terms of the question, if a therapeutic influence is also reasonable in slight symptomatic hyponatremia it is necessary to establish an accurate phenotyping of patients with hyponatremia, which quantifies the individual cognitive, motoric and psychological qualities.
Patients with hyponatremia will be examined on the basis of standardized neuropsychological and neurological tests. Following questions are to be answered with this study:
- Which cognitive, motoric and psychological functions are impaired due to hyponatremia?
- Is there a correlation between the extend of hyponatremia and the different test results?
- Is there an intraindividual difference in test results during hyponatremia and normal sodium concentrations?
Sponsor: University of Cologne
Current Primary Outcome: Assessment of Performance in individual tests [ Time Frame: Change in individual tests at Baseline and at the earliest 48 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of Cologne
Dates:
Date Received: April 23, 2013
Date Started: June 2012
Date Completion: December 2018
Last Updated: May 2, 2017
Last Verified: May 2017
