Clinical Trial: Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Exercise Versus Extended-Release Niacin in Patients With Coronary Heart Disease and Low High-Density Lipoproteins (HDL) Cholesterol: Effect on Lipid Profile and Endothelial Function

Brief Summary:

The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on

  • lipid profile
  • endothelial function as measured by ultrasound

The endothelium is the inner part of the blood vessels. Impaired endothelial function is known to be associated with atherosclerosis which can ultimately lead to diseases such as stroke, heart attack and others. Endothelial function can be assessed non-invasively by ultrasound.

Both interventions mentioned above have been shown to have a beneficial effect on lipid profile and endothelial function. However, the relative effects are unclear.


Detailed Summary: Comparison of physical exercise vs. extended-release niacin in patients with CAD and low HDL cholesterol (< 1,03 mmol/L) on lipid profile and endothelial function as measured by flow-mediated dilatation of radial artery. Secondary goals are the assessment of biochemical markers of atherosclerosis, expression of monocyte surface markers, oxidative stress and thrombogenicity.
Sponsor: University of Leipzig

Current Primary Outcome: relative effect on flow-mediated dilatation of radial artery [ Time Frame: 6 months ]

Original Primary Outcome: relative effect on flow-mediated dilatation of radial artery

Current Secondary Outcome:

  • lipid profile [ Time Frame: 6 months ]
  • biochemical markers of atherosclerosis [ Time Frame: 6 months ]
  • expression of monocyte surface markers [ Time Frame: 6 months ]
  • oxidative stress [ Time Frame: 6 months ]
  • thrombogenicity [ Time Frame: 6 months ]


Original Secondary Outcome:

  • relative effect on
  • - lipid profile
  • - biochemical markers of atherosclerosis
  • - expression of monocyte surface markers
  • - oxidative stress
  • - thrombogenicity


Information By: University of Leipzig

Dates:
Date Received: March 2, 2006
Date Started: March 2006
Date Completion:
Last Updated: July 29, 2012
Last Verified: July 2012