Clinical Trial: Hypoglycemia and Autonomic Nervous System Function
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Hypoglycemia and Autonomic Nervous System Function
Brief Summary: The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system and whether administration of a mineralocorticoid receptor antagonist modifies the effects of hypoglycemia on the autonomic nervous system
Detailed Summary:
Sponsor: Brigham and Women's Hospital
Current Primary Outcome:
- Modified Oxford method assessment of baroreflex function [ Time Frame: 1 day after euglycemic and hypoglycemic clamps ]
- Muscle sympathetic nerve activity [ Time Frame: 1 day after euglycemic and hypoglycemic clamps ]
- Catecholamine response to lower-body negative pressure [ Time Frame: 1 day after euglycemic and hypoglycemic clamps ]
- Modified Oxford method assessment of baroreflex function [ Time Frame: during euglycemic and hypoglycemic clamps ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Brigham and Women's Hospital
Dates:
Date Received: March 20, 2013
Date Started: January 2005
Date Completion: December 2015
Last Updated: March 20, 2013
Last Verified: March 2013
