Clinical Trial: Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Brief Summary: Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.

Detailed Summary:

This study employs a multi-center approach to evaluate cutaneous vasculitis across several forms of idiopathic vasculitis. Patients with cutaneous manifestations of vasculitis will be evaluated by teams of primary vasculitis care providers and Dermatologists in order to facilitate optimal selection of patients and sampling of lesions.

A punch skin biopsy at a site of active vasculitis will be the source of material for histopathologic and transcriptomic evaluation. The histopathology of cutaneous vasculitis will be characterized using a standardized approach.


Sponsor: Peter Merkel

Current Primary Outcome: Evaluation of clinical data and linked biopsy specimens [ Time Frame: 1 year ]

Describe cutaneous vasculitis across several different forms of systemic vasculitis using histopathology.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Pennsylvania

Dates:
Date Received: December 20, 2016
Date Started: January 2017
Date Completion: August 2019
Last Updated: February 21, 2017
Last Verified: February 2017