Clinical Trial: Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol: a Pilot Study

Brief Summary: Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.

Detailed Summary:
Sponsor: DongGuk University

Current Primary Outcome: Time to open eyes under investigator's command [ Time Frame: From cessation of propofol infusion to patient's eye opening (seconds) ]

After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.


Original Primary Outcome: Time to open eyes under investigator's command [ Time Frame: From cessation of propofol infusion to patient's eye opening (seconds) ]

After stopping propofol infusion, every 30 seconds, the caregiver will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.


Current Secondary Outcome:

  • Time to breath spontaneously [ Time Frame: From cessation of propofol infusion to patient's spontaneous breathing (sec) ]
    The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes.
  • Change of bispectral index (BIS) [ Time Frame: From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded. ]
    After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes.
  • Time to open mouth under investigator's command [ Time Frame: From cessation of propofol infusion to patient's mouth opening (seconds) ]
    After the patient opens the eyes, every 10 seconds, the investigator command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes.
  • Time to extubation [ Time Frame: From cessation of propofol infusion to extubation (sec) ]
    After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes.


Original Secondary Outcome:

  • Time to breath spontaneously [ Time Frame: From cessation of propofol infusion to patient's spontaneous breathing (sec) ]
    After the caregiver stops propofol infusion when the patient regain spontaneous breaths, the time will be recorded. The patients will be followed for an expected average of 10 minutes.
  • Change of bispectral index (BIS) [ Time Frame: From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded. ]
    After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes.
  • Time to open mouth under investigator's command [ Time Frame: From cessation of propofol infusion to patient's mouth opening (seconds) ]
    After stopping propofol infusion, every 30 seconds, the caregiver command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 10 minutes.
  • Time to extubation [ Time Frame: From cessation of propofol infusion to extubation (sec) ]
    After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes.


Information By: DongGuk University

Dates:
Date Received: February 6, 2012
Date Started: January 2012
Date Completion:
Last Updated: February 12, 2015
Last Verified: February 2015