Clinical Trial: High-Density Lipoprotein (HDL) Treatment Study

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Treatment Study for Severe High-Density Lipoprotein Deficiency

Brief Summary:

A low level of plasma high-density lipoprotein (HDL) cholesterol, "the good cholesterol", is the most common lipid abnormality observed in patients with a premature atherosclerotic cardiovascular disease. HDL carry excess cholesterol from peripheral tissues to the liver to be metabolized or excreted, a process known as reverse cholesterol transport.

Epidemiological studies have shown an inverse correlation between plasma levels of HDL cholesterol and the risk of cardiovascular disease. An increase in plasma HDL cholesterol levels by 1 mg/dL may reduce the risk of cardiovascular disease by 2 to 3%. The standard care of treatment for a low level of HDL cholesterol is: 1) lifestyle modifications including exercise, smoking cessation, weight control, moderate alcohol intake and decreased dietary fat intake - all patients are encouraged to follow these lifestyle modifications; 2) medications which can raise HDL cholesterol.

Currently used medications to treat lipid disorders can increase, in some extent, HDL cholesterol. These include niacin (vitamin B3), fibric acid derivatives (fibrates) and statins. However there is no data on the effect of these medications on severe cases of HDL deficiency. This project aims to determine whether currently available medications, used in standard medical practice for the treatment of lipoprotein disorders, can substantially increase HDL cholesterol in severe cases of HDL deficiencies.

Detailed Summary:

Objective and rationale. We have collected, in the past 15 years, a large group of patients with familial HDL cholesterol deficiency. In approximately 25% of index probands in our family studies, the genetic basis of HDL deficiency is identified at the molecular level. Approximately 20% of our severe HDL cholesterol deficient patients have mutations within the ABCA1 gene, while mutations at the apoA-I and SMPD1 genes have also been identified. In the present study, we wish to determine whether conventional lipid-regulating medication can substantially increase HDL cholesterol in patients with severe HDL deficiency. Anecdotal reports from our clinic suggest that patients with ABCA1 mutations do not respond to currently available medication; this will be more thoroughly ascertain in this protocol. In addition, examining patients with other genetic HDL deficiencies and familial forms (gene not yet identified) will provide insight on the treatment options for these patients. We feel it is important first whether currently recommended medication can effectively raise HDL cholesterol in these patients.

Study subjects. The subjects will include patients with familial HDL deficiency (HDL cholesterol < 5th percentile for age and gender, with at least one degree relative affected) and HDL deficiency with well-defined genetic mutation. We expect approximately 20-25 patients to enter the study.

Patients will be excluded if at least one of the following criteria is present:

• Triglycerides ≥ 5 mmol/L
• Diabetes
• Severe obesity (BMI ≥ 30)
• Alcohol intake > 21 drinks/week
• Untreated disease (thyroid, hepatic
  Sponsor: McGill University Health Center
  

  Current Primary Outcome: HDL cholesterol [ Time Frame: 9 months ]
  
  

  Original Primary Outcome:

  • Total cholesterol
  • Triglycerides
  • HDL cholesterol
  • LDL cholesterol
  • ApoA-I
  • ApoB
  • ALT
  • CK
  
  
  

  Current Secondary Outcome: apo AI [ Time Frame: 9 months ]
  
  

  Original Secondary Outcome:

  • Body mass index (weight and height)
  • Blood pressure
  • Symptoms of ischemic heart disease
  • Hepatic functions
  • Myopathic symptoms
  
  
  Information By: McGill University Health Center
  

  Dates:
  Date Received: April 5, 2007
  Date Started: November 2006
  Date Completion:
  Last Updated: June 2, 2008
  Last Verified: June 2008