Clinical Trial: Prevalence of Hyperventilation Syndrome in Difficult Asthma

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Prevalence of Hyperventilation Syndrome in Difficult Asthmatics Uncontrolled Despite a Daily Maximal Doses of Inhaled Treatment

Brief Summary: Most of asthmatics patients remain uncontrolled despite an inhaled steroids treatment. Chronic hyperventilation syndrome (also called Idiopathic Hyperventilation) occurs in 20 to 40% of asthmatic patients. The purpose of the study is to assess the prevalence of chronic hyperventilation syndrome in a specific population of difficult-to-treat asthmatics patients, those who receive daily high doses of inhaled steroids (≥ 1000 µg of fluticasone with an additional treatment by a long-acting beta 2-agonist (LABA) and who remain uncontrolled (Asthma control test (ACT) < 18). We plan to realize a systematic assessment of the diagnosis of chronic hyperventilation syndrome with the Nijmegen questionnaire, blood gases at rest, hyperventilation testing and Cardiopulmonary Exercise Testing(CPET). We also will collect demographic information as well as information about asthma history, asthma control and treatment.

Detailed Summary: There is only one visit. During this visit, each patient will complete self-questionnaires like Nijmegen, Hospital Anxiety and Depression Scale(HAD), Short-Form 36(SF36), and Asthma Quality of Life Questionnaire (AQLQ), The participants will have baseline spirometry and fractional exhaled nitric oxide measured at expiratory flow of 50 mL/s (FENO50), blood gases at rest, an hyperventilation challenge and Cardiopulmonary Exercise Testing(CPET) to determine accurately the presence or not of chronic hyperventilation syndrome. The diagnosis is confirmed by two positive tests (Nijmegen, Hyperventilation challenge and blood gases) and the final decision of a medical committee. The first step is to determine the prevalence oh this syndrome in this specific population. The second step is to assess the sensitivity, the specificity, the false positive rate and the false negative rate of the different parameters measured during the tests.
Sponsor: Assistance Publique - Hôpitaux de Paris

Current Primary Outcome: Diagnostic of the hyperventilation syndrome [ Time Frame: Up to 4 hours ]

value of Nijmegen questionnaire, of blood gases at rest, of hyperventilation testing and of CPET


Original Primary Outcome: Prevalence of the hyperventilation syndrome in difficult asthma [ Time Frame: Up to 3 years ]

Current Secondary Outcome:

  • Assess the diagnosis value of the nijmegen questionnaire. [ Time Frame: Up to 4 hours ]
  • Assess the diagnosis value of the blod gases at rest. [ Time Frame: up to 4 hours ]
  • Assess the diagnosis value of the hyperventilation challenge. [ Time Frame: Up to 4 hours ]
  • Assess the diagnosis value of the CPET. [ Time Frame: Up to 4 hours ]


Original Secondary Outcome:

  • Assess the diagnosis value of the nijmegen questionnaire. [ Time Frame: Up to 3 years ]
  • Assess the diagnosis value of the blod gases at rest. [ Time Frame: Up to 3 years ]
  • Assess the diagnosis value of the hyperventilation challenge. [ Time Frame: Up to 3 years ]
  • Assess the diagnosis value of the CPET. [ Time Frame: Up to 3 years ]


Information By: Assistance Publique - Hôpitaux de Paris

Dates:
Date Received: May 22, 2013
Date Started: April 2013
Date Completion: November 2016
Last Updated: October 7, 2016
Last Verified: September 2016