Clinical Trial: Treatment of Hyperuricemia in Patients With Heart Failure

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Hyperuricemia and the Effects of the Uricosuric Agents Benzbromarone in Patients With Chronic Heart Failure

Brief Summary: The study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.

Detailed Summary: Hyperuricemia is often observed in patients with congestive heart failure (CHF). It has been reported that hyperuricemia is related to exercise capacity, inflammation markers and diastolic dysfunction in such patients. In addition, hyperuricemia in CHF relates to both symptomatic status (i.e. morbidity) as well as impaired prognosis (i.e. mortality). Hyperuricemia is likely to play an important role in the pathophysiology of CHF. Up-regulation of xanthine oxidase (XO) activity in CHF has been shown to contribute to higher uric acid (UA) in CHF and the therapeutic concept of XO inhibition has shown beneficial effects in a number of surrogate markers in these patients. The XO inhibition accounts for substantial decrease in oxygen radical load, the latter is discussed as the main benefit of XO inhibition treatment in hyperuricemic patients. However, whether high uric acid itself is important or merely a marker of XO activity (and hence of increased radical accumulation) is currently under discussion. Therefore, this study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.
Sponsor: Tottori University Hospital

Current Primary Outcome:

  • parameters of echocardiography at 16 weeks
  • BNP levels at 16 weeks


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • parameters of glucose metabolism at 16 weeks
  • Parameters of lipid metabolism at 16 weeks


Original Secondary Outcome: Same as current

Information By: Tottori University Hospital

Dates:
Date Received: January 12, 2007
Date Started: January 2004
Date Completion: December 2005
Last Updated: January 12, 2007
Last Verified: January 2007