Clinical Trial: Prednisone for Heart Failure Patients With Hyperuricemia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Prednisone in Uric Acid Lowering in Symptomatic Heart Failure PATients With Hyperuricemia (PUSH-PATH Study 2)
Brief Summary: Hyperuricemia is a very common finding in patients with heart failure. It is usually related to diuretic use and deteriorated renal function. The recently evidence showed that uric acid (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could dramatically lower UA while improving renal function. Thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering UA and could improve renal function at the same time.
Detailed Summary:
Sponsor: Hebei Medical University
Current Primary Outcome: Change from baseline in uric acid level [ Time Frame: 4 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Change from baseline in creatinine clearance rate [ Time Frame: 4 weeks ]
- Daily urine volume [ Time Frame: 4 weeks ]
- Body weight [ Time Frame: 4 weeks ]
- patient assessed dyspnea and physician assessed global clinical status [ Time Frame: 4 weeks ]
- 6-minute walking distance [ Time Frame: 4 weeks ]
- NYHA functional class [ Time Frame: 4 weeks ]
Original Secondary Outcome: Same as current
Information By: Hebei Medical University
Dates:
Date Received: April 30, 2014
Date Started: December 2013
Date Completion:
Last Updated: August 31, 2010
Last Verified: June 2009
