Clinical Trial: Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men

Brief Summary: Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.

Detailed Summary:
Sponsor: University of Copenhagen

Current Primary Outcome: Skeletal Muscle Hypertrophy (lean body mass in Kilograms) [ Time Frame: 2 days ]

Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)


Original Primary Outcome: Same as current

Current Secondary Outcome: Left Ventricular Hypertrophy (mass in grams) [ Time Frame: 1 day ]

Left Ventricular Mass (g) will be measured by echocardiography of the heart


Original Secondary Outcome: Same as current

Information By: University of Copenhagen

Dates:
Date Received: September 12, 2015
Date Started: November 2013
Date Completion:
Last Updated: March 14, 2016
Last Verified: March 2016