Clinical Trial: The Treatment of Hepatocirrhosis and Portal Hypertension
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Treatment of Gastroesophageal Varices Accompanied With Splenomegaly or Hypersplenism of Hepatocirrhosis and Portal Hypertension
Brief Summary: This study compare the efficiency of partial splenic embolization +endoscopical therapy with endoscopical therapy alone in gastroesophageal variceal haemorrhage accompanied with splenomegaly or hypersplenism of hepatocirrhosis and portal hypertension treatment.
Detailed Summary: Endoscopic therapy is the mature treatment of gastroesophageal variceal haemorrhage and PSE is an effective method for treatment of the hypersplenism and portal hypertension. Existing researches show that endoscopic therapy + PSE is more effective than endoscopic therapy alone in prevention of esophageal varices bleeding recurrence in the patients with liver cirrhosis. However, there is few articles which proved long-term effectiveness of endoscopic therapy + PSE, it needs further research on this issue. This study compares the efficiency of partial splenic embolization +endoscopic therapy with endoscopic therapy alone in the treatment of gastroesophageal variceal haemorrhage accompanied with splenomegaly or hypersplenism in the patients with hepatocirrhosis and portal hypertension.
Sponsor: Yanjing Gao
Current Primary Outcome: recurrent rate of gastroesophageal varices [ Time Frame: 3 years ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- rehaemorrhage ratio [ Time Frame: 3 years ]
- mortality [ Time Frame: 3 years ]
Original Secondary Outcome: Same as current
Information By: Qilu Hospital of Shandong University
Dates:
Date Received: May 8, 2016
Date Started: February 2016
Date Completion: February 2019
Last Updated: July 4, 2016
Last Verified: May 2016
