Clinical Trial: Epidemiology and Co-Reactivity of Novel Surfactant Allergens

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Epidemiology and Co-Reactivity of Novel Surfactant Allergens

Brief Summary: The primary objectives of this study are to identify positivity rates to three novel surfactants (ingredients used in soaps, detergents, and other cleansers that serve to lower the surface tension of the skin and remove debris) and co-reactivity with other surfactants in patients with known surfactant sensitivity on skin patch testing. The investigators hypothesize that subjects who previously tested positive to known allergenic surfactants (cocamidopropyl betaine, stearamidopropyl dimethylamine, dimethylaminopropylamine, coconut diethanolamide, oleamidopropyl dimethylamine, and decyl glucoside) may demonstrate co-reactivity to the three novel surfactant sensitizers (sodium lauroyl sarcosinate, isostearmidopropyl morpholine lactate, and disodium lauroamphodiacetate) on skin patch testing.

Detailed Summary:
Sponsor: Minneapolis Veterans Affairs Medical Center

Current Primary Outcome: Number of participants with positive skin patch test reaction, scored using the North American Contact Dermatitis Group (NACDG) criteria, to three novel surfactant antigens. [ Time Frame: Five days ]

NACDG Scoring as follows: 6=no reaction, 4=doubtful (faint erythema with no induration), 1= mild (erythema, induration, +/- papules), 2=moderate (erythema, induration, papules, vesicles), 3=severe (intense erythema, induration, coalescing vesicles, bullae, spreading), and 5= irritant.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Minneapolis Veterans Affairs Medical Center

Dates:
Date Received: August 6, 2015
Date Started: August 2015
Date Completion:
Last Updated: September 22, 2016
Last Verified: September 2016