Clinical Trial: Efficacy of Platelet-rich Plasma (PRP) in the Treatment of Dark Circles Under the Eyes

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy of Platelet-Rich Plasma (PRP) in the Treatment of Periorbital Hyperpigmentation

Brief Summary: 10 ml of blood from each patient will be drawn. This blood specimen will be centrifuged in a specific way to get 1 ml of platelet rich plasma (PRP). PRP will be injected into the the skin under the eyes. The treatment course consists of three sessions of PRP injections with one-month intervals between the sessions.

Detailed Summary:

Background:

Dark circles around the eyes is a common problem pretending with relatively dark eyelids concerns many patients, especially women, because of the inconvenience caused by esthetic and negative impact on the psyche and the patient's quality of life. There are several causing factors (such as sun exposure, smoking, alcohol, sleep deprivation, genetic and structural factors). variety of treatments have been used for this situation , but without clear results.

The term 'Platelet-Rich Plasma (PRP)' is a general term used to describe hanging plasma that has been obtained from whole blood with concentration of platelets higher than normal concentration found in the circulating blood. PRP's work mechanism depends on the fact that platelets contain important substances called (growth factors), which have a known role in the process of reform and renewal of tissues.

Aim of the research:

This study was designed to evaluate the effectiveness of (PRP) injection in the treatment of dark circles under the eyes. This is an uncontrolled open therapeutic trial study which will be performed at the Hospital of Dermatology and Venereology of Damascus University in Damascus, Syria during the period from June 2016 to June 2017.

The results will be assessed by standardized digital photography month after each injection and three months after the latest assessment with the assistant of skin colors scale. In addition, the patient's satisfaction with the results and any treatment-related side effects will be recorded.


Sponsor: Damascus University

Current Primary Outcome: Change in Skin Color [ Time Frame: Color shade will be measured at one month following the first injection (T1) and at three months following the third injection (T2) ]

Standardized digital photographs will be taken and a color scale will be used


Original Primary Outcome: Same as current

Current Secondary Outcome: Satisfaction [ Time Frame: Satisfaction will be measured at three months following the last injection. ]

Patients' satisfaction will be measured on a visual analog scale (VAS)


Original Secondary Outcome: Same as current

Information By: Damascus University

Dates:
Date Received: April 11, 2017
Date Started: June 17, 2016
Date Completion:
Last Updated: May 13, 2017
Last Verified: May 2017