Clinical Trial: Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation Following Q-switched Nd:YAG 532 nm Laser for Treatment of Facial Lentigines - A Pi

Brief Summary: To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.

Detailed Summary:

  • The incidence of post inflammatory hyperpigmentation (PIH) after treating lentigines with Q-switched Nd:YAG laser was 78.3%.
  • It has been found that the incidence of PIH decreased to 40% after applied topical high potency steroid 2 days after the laser treatment.
  • By these anti-inflammatory and anti-PIH effects of the high potency steroid, the investigators aimed that the application of steroid 2 days before and 2 days after the laser treatment would be better reduction in the incidence of PIH after Q-switched Nd:YAG laser.

Sponsor: Mahidol University

Current Primary Outcome: The incidence of post inflammatory hyperpigmentation [ Time Frame: 2 weeks ]

By investigator's observation.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Side effects of topical steroid [ Time Frame: Follow-up 2, 3, 4, 8, 12 and 24 weeks after the last treatment ]
    By investigators' observation of telangiectasia, erythema or atrophy.
  • The patients satisfaction [ Time Frame: Follow-up 4, 8, 12 and 24 weeks after the last treatment ]
    By using Quartile grading scale of improvement; 0 = not improve, 1= 1-25% improvement, 2 = 26-50% improvement, 3 = 51-75% improvement and 4 = 76-100% improvement


Original Secondary Outcome: Same as current

Information By: Mahidol University

Dates:
Date Received: June 27, 2015
Date Started: February 2015
Date Completion:
Last Updated: May 31, 2016
Last Verified: May 2016