Clinical Trial: Cognitive Processes Study in Obese Women With and Without Eating Disorders

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Cognitive Processes Study in Obese Women With and Without Eating Disorders : Research of Electro-physiological Similarity With Addiction

Brief Summary:

The P300 is one of the cognitive wave of the Event-Related Potential (ERP) that is used to investigate the cognitive process. The P300 component are accepted as electro-physiological markers of neuropsychiatric disorders like alcoholism or drug addiction.

Recent scientific data suggest that eating disorders, leading to weight gain and obesity, will be similar of those of drug addiction: it is the incentive sensitization theory that implicates the dopaminergic reward system.

The aim of this cross-sectional study is to investigate the alteration of P300 auditory ERP in obese women with eating disorders in comparison with obese and lean women without eating disorders.


Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome: P300 amplitude [ Time Frame: At the beginning of the exploration visit (when patient is fasting) that will take place between 1 and 15 days after inclusion ]

The auditory event-related potentials measure will be elicited with an auditory oddball paradigm. The activity will be recorded thanks to electroencephalography from frontal, central and parietal electrodes, using an electrode cap.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Auditory ERP ( latency P300, amplitude and latency of N2 wave recorded from frontal, central and parietal electrode) [ Time Frame: fasting (up to 15 days) ]
    The technique of auditory ERP will be an auditory discriminated task paradigm
  • assessment of dietary restraints and disinhibition [ Time Frame: fasting (up to 15 days) ]
    Participants will complete self-report questionnaires including Three-Factor Eating Questionnaire and Eating Disorders Inventory. The lean subjects should not have TFEQ disinhibition score more than 8. The obese subjects will be separated on two groups depending on TFEQ dishinibition score (strictly greater than 8, the obese with eating disorder, less than or equal 8, obese without eating disorder).
  • glucose, insulin, leptin and ghrelin plasmatic rate [ Time Frame: fasting (up to 15 days) ]
    respectively reverse-phase high-performance liquid chromatography (RP-HPLC), ImmunoRadio Metric (IRMA) and ELISA assay
  • dopamine D2 receptor Taq 1 polymorphism [ Time Frame: fasting (up to 15 days) ]
    Real time PCR
  • Dietary intake and eating patterns [ Time Frame: At day 1 and at day 15 ]
    Women will be interviewed by dietician, using a 24 h food questionnaire with additional questions regarding health and eating habits


Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: September 2, 2013
Date Started: July 2013
Date Completion:
Last Updated: August 26, 2016
Last Verified: August 2016