Clinical Trial: Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium and Bone Metabolism After Surgery?

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium and Bone Metabolism After Successful Surgery in Patients Without Osteoporosis?

Brief Summary:

Primary Hyperparathyroidism (pHPT) increases bone turnover and resorption and thus calcium efflux out of bone. After successful surgical treatment of pHPT, bone takes up calcium again which may result in secondary hyperparathyroidism or even "hungry bone syndrome". Until today there are no studies about this problem helping to develop recommendations or guidelines how to prevent these symptoms.

Study hypothesis: Calcium and vitamin D intake after surgery for PHPT protects the bone by keeping PTH in the normal range (less secondary, reactive hyperparathyroidism), prevents hungry bone- syndrome and improve bone-turnover markers (osteoporosis protection).


Detailed Summary:
Sponsor: Medical University of Vienna

Current Primary Outcome: Parathyroid hormone [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • BMD of lumbar spine, femoral neck and radius [ Time Frame: 1 year ]
  • Adverse effects calcium or vitamin D [ Time Frame: 1 year ]
  • Other biochemical markers of bone metabolism [ Time Frame: 1 year ]


Original Secondary Outcome: Same as current

Information By: Medical University of Vienna

Dates:
Date Received: September 8, 2009
Date Started: September 2009
Date Completion: September 2017
Last Updated: March 14, 2016
Last Verified: March 2016