Clinical Trial: Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation

Brief Summary: Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process are not fully explored. The development of new instruments for the non-invasive measurement of oxygen tension in retinal vessels now allows for the more precise investigation of these physiological processes. The current study seeks to evaluate the retinal oxygen saturation in healthy subjects while breathing different oxygen mixtures to achieve a hypoxic and a hyperoxic state.

Detailed Summary:
Sponsor: Medical University of Vienna

Current Primary Outcome: Retinal oxygen saturation [ Time Frame: On the study day - during each breathing period (6 times) ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Retinal blood flow [ Time Frame: On the study day - during each breathing period (6 times) ]

Original Secondary Outcome: Same as current

Information By: Medical University of Vienna

Dates:
Date Received: June 14, 2012
Date Started: June 2012
Date Completion:
Last Updated: January 29, 2013
Last Verified: January 2013