Clinical Trial: Hyperoxic Oxidative Stress During Abdominal Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparing the Effect of Hyperoxic and Conventional Fraction of Inspired Oxygen on Oxidative Stress During Abdominal Surgery.

Brief Summary: Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

Detailed Summary:
Sponsor: Istanbul University

Current Primary Outcome: oxidant and antioxidant response [ Time Frame: 4 hours ]

As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated


Original Primary Outcome: superoxide dismutase (SOD) [ Time Frame: 4 hours ]

Superoxide dismutase (SOD)- (a response to oxidative stress) levels will be evaluated in plasma and bronchoalveolar lavage material taken after intubation and prior to extubation


Current Secondary Outcome: Hemodynamics [ Time Frame: 4 hours ]

The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics.


Original Secondary Outcome: Expiratory Tidal Volume [ Time Frame: 4 hours ]

Expiratory tidal volumes will be measured and compared both before anesthesia induction and 15 minutes after extubation with Wright Respirometer


Information By: Istanbul University

Dates:
Date Received: February 14, 2013
Date Started: February 2013
Date Completion:
Last Updated: April 8, 2015
Last Verified: April 2015