Clinical Trial: Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Prospective Randomized Double Blind Placebo Controlled Intervention Study of the Effect of Dexamethasone on the Sodium Retention in Patients With Liver Cirrhosis
Brief Summary: Accumulation of salt and water in patients with liver disease (so called liver cirrhosis) is possibly related to the increased effect of steroid hormones on salt reabsorption in the kidney. By reducing overall steroid production with the dexamethasone the accumulation of salt and water could be prevented.
Detailed Summary:
Sponsor: University Hospital Inselspital, Berne
Current Primary Outcome: Daily sodium excretion of sodium in the urine [ Time Frame: 4 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Daily potassium excretion [ Time Frame: 4 days ]
- weight reduction [ Time Frame: 4 days ]
- Reduction of doses of diuretics [ Time Frame: 4 days ]
- Reduction of ascites [ Time Frame: 4 days ]
- Reduction of cortisol excretion in the urine [ Time Frame: 4 days ]
- Reduction of cortisol levels in the urine [ Time Frame: 4 days ]
Original Secondary Outcome:
- Daily potassium excretion [ Time Frame: 4 days ]
- weight reduction [ Time Frame: 4 days ]
- Reduction of doses of diuretics [ Time Frame: 4 days ]
- Reduction of ascites [ Time Frame: 4 days ]
- Reduction of cortisol levels and cortisol excretion in the urine [ Time Frame: 4 days ]
Information By: University Hospital Inselspital, Berne
Dates:
Date Received: March 7, 2011
Date Started: February 2011
Date Completion:
Last Updated: April 17, 2013
Last Verified: April 2013
