Clinical Trial: Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients
Brief Summary:
Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH.
Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia.
Design: Prospective observational study.
Detailed Summary:
Sponsor: University Hospital, Basel, Switzerland
Current Primary Outcome: diagnostic accuracy of copeptin within hospital stay [ Time Frame: participants will be followed for up to 1 year ]
Original Primary Outcome: diagnostic accuracy of copeptin within hospital stay [ Time Frame: participants will be followed for the duration of hospital stay (for on average 14 days) ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University Hospital, Basel, Switzerland
Dates:
Date Received: September 30, 2011
Date Started: October 2011
Date Completion:
Last Updated: November 30, 2015
Last Verified: November 2015