Clinical Trial: Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia

Brief Summary: The objective of this study is to determine the best insulin regimen for hospitalized patients who receive high doses of steroids who have high blood glucose.

Detailed Summary: The overall study objective of this research is to establish the efficacy and assure the safety of achieving glycemic control in hospitalized patients who receive greater than physiologic doses of steroids. This study will compare 2 methods of achieving glycemic control in hospitalized patients who develop steroid-induced hyperglycemia (blood glucose (BG) >180 mg/dL): 1) a study-specific steroid NPH dosing algorithm plus standard recommended care (Experimental group) vs. 2) the standard recommended care (Methodist Hospital Complete Insulin Orders (Control group).
Sponsor: HealthPartners Institute

Current Primary Outcome: Mean Blood Glucose. [ Time Frame: discharge or until after their 5th day in the hospital ]

as stated above


Original Primary Outcome: the proportion of blood glucose readings between 70 and 180 mg/dL, inclusive [ Time Frame: discharge or until after their 5th day in the hospital ]

as stated above


Current Secondary Outcome: the Mean Blood Glucose of All Blood Glucose Readings [ Time Frame: starting 3 hours after the initial index BG>180 measure, across the entire hospital stay or up through 5 days if hospital LOS is > 5 days ]

as stated above


Original Secondary Outcome: Same as current

Information By: HealthPartners Institute

Dates:
Date Received: August 16, 2010
Date Started: August 2010
Date Completion:
Last Updated: November 30, 2015
Last Verified: November 2013