Clinical Trial: Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Cerebral Hyperemia During Emergence From General Anesthesia for Craniotomy of Patients With Brain Tumor

Brief Summary: Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.

Detailed Summary: 30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.
Sponsor: Huashan Hospital

Current Primary Outcome:

  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: before general anesthesia ]
    It was the baseline mean blood flow velocity in middle cerebral artery.
  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: after surgery at extubation (average surgery duration: craniotomy group 214min, abdominal group 207min) ]
  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: 30min after extubation ]
  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: 60min after extubation ]
  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: 90min after extubation ]
  • Mean Blood Flow Velocity in Middle Cerebral Artery [ Time Frame: 120min after extubation ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: before general anesthesia ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: at extubation ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: 30min after extubation ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: 60min after extubation ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: 90min after extubation ]
  • Oxygen Saturation of Jugular Venous Bulb [ Time Frame: 120min after extubation ]


Original Primary Outcome: changes in mean velocity of middle cerebral artery [ Time Frame: before general anesthesia and in 2 hours after tracheal extubation ]

change from baseline in mean velocity of middle cerebral artery at tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 30 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 60 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 90 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 120 minutes after tracheal extubation


Current Secondary Outcome:

Original Secondary Outcome: changes in saturation of jugular vein bulb [ Time Frame: before general anesthesia and in 2 hours after tracheal extubation ]

change from baseline in mean velocity of middle cerebral artery at tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 30 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 60 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 90 minutes after tracheal extubation; change from baseline in mean velocity of middle cerebral artery at 120 minutes after tracheal extubation


Information By: Huashan Hospital

Dates:
Date Received: July 8, 2012
Date Started: November 2012
Date Completion:
Last Updated: May 15, 2013
Last Verified: May 2013