Clinical Trial: Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Non-steroid Anti-inflammatory Drug on Travoprost-induced Conjunctival Hyperemia and Intraocular Pressure Reduction in Normal Eyes

Brief Summary:

PG-analogues induce hyperemia as one of side effects in addition to IOP reduction.

IOP reduction is caused by direct FP receptor stimulation, but the cause of hyperemia is not clarified.

Because FP receptor stimulation induce intrinsic production of PGs, hyperemia or IOP reduction may be due to secondary induced PGs.

Thus, pretreatment with NSAID may affect the PG-analogue induced hyperemia or IOP reduction.


Detailed Summary:
Sponsor: Tokyo University

Current Primary Outcome: IOP reduction [ Time Frame: 1 day ]

effect of NSAID on IOP reduction by travoprost


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Tokyo University

Dates:
Date Received: July 20, 2011
Date Started: September 2008
Date Completion:
Last Updated: May 12, 2014
Last Verified: May 2014