Clinical Trial: Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Relationship Between Elevated Serum Serotonin Levels in Symptomatic Patients With Hyperemezis

Brief Summary: Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.

Detailed Summary:

The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.

It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.

The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.

Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Current Primary Outcome: serum serotonin levels in hiperemezis gravidarum [ Time Frame: 6-14week pregnancy ]

Original Primary Outcome: Same as current

Current Secondary Outcome: ıs there any assosiation between serotonin levels and severity of symptoms in pregnant women with hiperemezis [ Time Frame: 6-14week pregnancy ]

Original Secondary Outcome: Same as current

Information By: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Dates:
Date Received: November 13, 2013
Date Started: October 2013
Date Completion: March 2014
Last Updated: November 18, 2013
Last Verified: November 2013