Clinical Trial: Endothelial Dysfunction in Hyperemesis Gravidarum
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Endothelial Dysfunction in Hyperemesis Gravidarum
Brief Summary: The purpose of the study is to determine serum inflammatory adhesion molecules levels in hyperemesis gravidarum
Detailed Summary:
The study population consisted of 2 groups; (1) the hyperemesis gravidarum group, consist of 25 pregnant women who developed dehydration due to HG between 6 and 13 gestational weeks and between 18 and 35 years (2) the normal pregnancy group, consisting of 25 pregnant women.
HG was defined according to the fallowing American College of Obstetricians and Gynecologists (ACOG) criteria; severe nausea and vomiting resulted in 5% weight loss with regard to pre-gestation or vomiting more than 3 times and 3-5 % weight loss with ketonuria. The diagnosis of dehydration was clinically defined and patients with moderate and severe dehydration were included in the study. As clinical findings; Weight loss, capillary recall time, dry mucous membranes, dry eye, pulse rate, systolic blood pressure, respiration, skin turgor deterioration and urine output were evaluated.
Other pathologies causing nausea and vomiting like; gastroenteritis, gastroparesis, gall duct diseases, hepatitis, peptic ulcers, appendicitis, pyelonephritis, ovarian torsion, urinary tract stones, diabetic ketoacidosis, hyperthyroidism, hyperparathyroidism, migraine, pseudo tumor cerebra, vestibular diseases were excluded from the study.Patients were excluded from the study in the presence of pregestational diabetes chronic hypertension, chronic liver and renal failure, preeclampsia history, multiple pregnancy, hyperlipidemia, hypercholesterolemia, obesity, tobacco use, NSAID drug use, infection within the last three months and surgery within the last month that could cause endothelial dysfunction.
Blood and urine specimens were collected from the patients with HG during hospitalization and during regular clinic visits in control group. The 2mL of blood samples were withdrawn into serum-separating tubes for the measurements
Sponsor: Kayseri Education and Research Hospital
Current Primary Outcome: Serum inflammatory adhesion molecules in hyperemesis gravidarum [ Time Frame: 4 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Kayseri Education and Research Hospital
Dates:
Date Received: December 8, 2016
Date Started: December 2016
Date Completion: March 2017
Last Updated: December 8, 2016
Last Verified: December 2016
