Clinical Trial: Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
Brief Summary: The proposed study will measure the time from the end of surgery until the time patients meet the discharge criteria from the postoperative anesthesia care unit and the time from the end of surgery until the patients regained cognitive function after anesthesia.
Detailed Summary: Hypercapnia has been used in conjunction with hyperpnoea to provide a more rapid return of responsiveness after inhaled anesthesia. In our first clinical study with isoflurane we confirmed that the time from turning off the vaporizer to opening of eyes was shortened by an average of 62% when the minute ventilation was elevated and the end tidal carbon dioxide concentration was kept at 52 mmHg rather than 28 mmHg during emergence. In our second study we found that hypercapnia and hyperpnoea accelerated recovery proportionately for sevoflurane and desflurane. The benefits of accelerating subject recovery in the operating room may extend to the entire recovery period if the subject is more alert and easier to care for when they arrive in the post anesthesia care unit.
Sponsor: University of Utah
Current Primary Outcome: Recovery From Anesthesia [ Time Frame: up to 2 hours ]
Original Primary Outcome: decrease in time to meet discharge criteria from the PACU [ Time Frame: Phase 1 anesthesia recovery ]
Current Secondary Outcome: Return of Cognitive Function [ Time Frame: up to 30 minutes ]
Original Secondary Outcome: a reduction in the incidence of adverse events when hypercapnic hyperpnoea is used during emergence. [ Time Frame: Phase 1 anesthesia recovery ]
Information By: University of Utah
Dates:
Date Received: June 30, 2008
Date Started: March 2008
Date Completion:
Last Updated: August 19, 2016
Last Verified: August 2016