Clinical Trial: Treatment for Calcium Phosphate Kidney Stone Disease

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Pharmacological Therapy for Calcium Phosphate Urolithiasis

Brief Summary: The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

Detailed Summary:

We will examine in two short-term placebo-controlled cross-over metabolic studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of CaP stone formers. The first study will be conducted in hypocitraturic CaP stone formers without hypercalciuria, and will compare the effects of potassium citrate, citric acid and placebo.

The second study will be conducted in hypercalciuric CaP stone formers on a thiazide diuretic who require potassium supplementation, and will compare the effects of potassium chloride alone, potassium chloride + citric acid, and potassium citrate alone. Physicochemical assays will be applied in addition to computer-based stone risk prediction programs to assess risk of stone recurrence.

Sponsor: University of Texas Southwestern Medical Center

Current Primary Outcome: Urinary calcium phosphate saturation [ Time Frame: 2 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Texas Southwestern Medical Center

Dates:
Date Received: December 14, 2012
Date Started: July 2012
Date Completion: July 2018
Last Updated: October 27, 2016
Last Verified: October 2016