Clinical Trial: Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Randall's Plaques: Pathogenesis and Relationship to Nephrolithiasis
Brief Summary:
Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown.
The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the papilla. The investigators have noticed that persons who form kidney stones seem to have more papilla with stones attached. They propose to study these areas of the papilla, called Randall's plaques (named after their discoverer), in patients undergoing surgery for kidney stones.
Detailed Summary: In order to attempt to explain the pathogenesis of renal calculi, the investigators videotape and document the location and characteristics of each stone, papillae and calyces. One or more small papillary biopsies are taken for analysis to help determine the point of origin of the kidney stone and histological studies are undertaken to determine tissue differences amongst different types of stone formers. Approximately one month after surgery, metabolic studies are undertaken to further review potential causes of stone formation.
Sponsor: Indiana Kidney Stone Institute
Current Primary Outcome: To find out why people form stones by comparing 24 urine collections, biopsy and anatomy to other patients who do not form stones and other patients who do form stones to see if the differences are significant [ Time Frame: One year from study completion ]
Original Primary Outcome: To find out why people form stones by comparing 24 urine collections, biopsy and anatomy to other patients that do not form stones and other patients that do form stones to see if the differences are significant.
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Indiana Kidney Stone Institute
Dates:
Date Received: September 12, 2005
Date Started: November 1998
Date Completion: December 2018
Last Updated: February 14, 2017
Last Verified: August 2016
