Clinical Trial: Low Salt Diet in Idiopathic Hypercalciuria

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Calcium Nephrolithiasis: Clinical Characteristics and Nutritional Determinants

Brief Summary:

Randomized clinical trial comparing water therapy plus low-salt diet to water therapy alone in patients affected by idiopathic calcium nephrolithiasis.

Treatment duration: three months Primary end-point: correction of hypercalciuria Main inclusion criteria: calcium stone formers with idiopathic hypercalciuria, with at least one stone expelled and analyzed by infrared spectrophotometry; presence of hypercalciuria (>300 mg/day in males and >200 mg/day in females); 18-65 years.

Main exclusion criteria: primary hyperparathyroidism, primary hyperoxaluria, enteric hyperoxaluria, bowel resection, inflammatory bowel disease, renal tubular acidosis, sarcoidosis, sponge kidney, hyperthyroidism, use of hypercalciuric drugs such as Vitamin D, acetazolamide, anti-epileptic drugs

Detailed Summary:
Sponsor: University of Parma

Current Primary Outcome: Normalization of urinary calcium levels

Original Primary Outcome: Same as current

Current Secondary Outcome: Change in urinary stone risk factors (e.g. urinary calcium, oxalate and sodium excretion); blood pressure reduction

Original Secondary Outcome: Same as current

Information By: University of Parma

Dates:
Date Received: October 29, 2009
Date Started: January 2005
Date Completion:
Last Updated: October 29, 2009
Last Verified: October 2009