Clinical Trial: Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
Brief Summary:
Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.
Detailed Summary:
Study hypothesis.
Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.
This may result in higher extraosseous calcification and higher pulse wave velocity
∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"
Sponsor: Universitaire Ziekenhuizen Leuven
Current Primary Outcome:
- correlation between calcium increase and pulse wave velocity
- correlation between calcium change and pth change
Original Primary Outcome: Same as current
Current Secondary Outcome:
- correlation between calcium increase and vascular calcifications
- correlation between calcium change and bone markers
Original Secondary Outcome: Same as current
Information By: Universitaire Ziekenhuizen Leuven
Dates:
Date Received: June 12, 2007
Date Started: June 2007
Date Completion:
Last Updated: January 15, 2010
Last Verified: June 2007
