Clinical Trial: Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effect of Free Fatty Acids on Androgen Precursors in Vivo in Healthy Young Women
Brief Summary: The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
Detailed Summary:
Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown.
Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.
Sponsor: Charite University, Berlin, Germany
Current Primary Outcome: change in adrenal androgens [ Time Frame: 1 day ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- urinary androgen excretion [ Time Frame: 1 day ]
- glucocorticoid metabolism and urinary glucocorticoid excretion [ Time Frame: 1 day ]
Original Secondary Outcome: urinary androgen excretion [ Time Frame: 1 day ]
Information By: Charite University, Berlin, Germany
Dates:
Date Received: May 14, 2007
Date Started: December 2006
Date Completion:
Last Updated: July 23, 2008
Last Verified: May 2007
