Clinical Trial: Effects of Androgen Administration on Inflammation in Normal Women
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effects of Oral Androgen Administration on Hyperglycemia-Induced Inflammation in Lean Reproductive-Age Women
Brief Summary: The hypothesis of this study is that DHEA administration to increase male hormone in healthy normal-weight young women to levels present in women with Polycystic Ovary Syndrome will cause an inflammatory response in white blood cells in the fasting state, and in response to glucose ingestion.
Detailed Summary:
Sponsor: Mayo Clinic
Current Primary Outcome: Nuclear factor kappa B (NFkappaB) activation [ Time Frame: 0 and 2 hours after glucose ingestion ]
Original Primary Outcome: Nuclear factor kappa B (NFkappaB) activation [ Time Frame: 1 year ]
Current Secondary Outcome: Insulin sensitivity [ Time Frame: 0 and 5 days after DHEA or placebo ]
Original Secondary Outcome: Insulin sensitivity [ Time Frame: 1 year ]
Information By: Mayo Clinic
Dates:
Date Received: December 15, 2012
Date Started: December 2006
Date Completion:
Last Updated: November 14, 2013
Last Verified: December 2012