Clinical Trial: Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Therapeutic Thoracentesis on Cardiopulmonary Function in Patients With Congestive Heart Failure Complicated With Large to Massive Pleural Effusion

Brief Summary: Transudative pleural effusions are a common manifestation of patients with congestive heart failure. Severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical treatment. Therapeutic thoracenteses (TT) may be indicated in these patients and can produce marked relief of symptoms. However, the underlying effect of TT on gas exchange and respiratory mechanics in theses patients remains unclear. The researchers' hypothesis is that,TT may improve arterial oxygenation and respiratory mechanics in patients with congestive heart failure complicated by large pleural effusions.

Detailed Summary:
Sponsor: Taipei Medical University Hospital

Current Primary Outcome: Vital signs, minute volume, expiratory tidal volume, dynamic compliance, arterial oxygen saturation and arterial blood gases, the volume of pleural fluid removed, and the changes in pleural liquid pressure and pleural space elastance [ Time Frame: 15 minutes after therapeutic thoracentesis ]

Original Primary Outcome: Blood pressure, respiratory rate, heart rate, minute volume, expiratory tidal volume, pulse oxygen saturation (SpO2), arterial blood gases and total amount of pleural effusion drained [ Time Frame: 15 minutes after therapeutic thoracentesis ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Taipei Medical University Hospital

Dates:
Date Received: February 25, 2008
Date Started: March 2007
Date Completion:
Last Updated: December 28, 2010
Last Verified: December 2010