Clinical Trial: Thoracoscopic Mesh Repair of Diaphragmatic Defects for Hepatic Hydrothorax

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Thoracoscopic Mesh Repair of Diaphragmatic Defects for Hepatic Hydrothorax: 10 Years' Experience From a Single Large-volume Center

Brief Summary: The management of refractory hepatic hydrothorax is challenging and usually unsuccessful. The study will discuss the perioperative treatment, effectiveness, and morphology of diaphragmatic defects of hepatic hydrothorax in thoracoscopic mesh repair. Risk factors associated with increased three-month mortality in these critically ill patients will be studied.

Detailed Summary:

Objective The objective was to analyze the outcomes of thoracoscopic mesh repair for hepatic hydrothorax (HH) at the institution of the investigators during the past 10 years.

Methods A total of 63 patients with refractory HH, who underwent thoracoscopic mesh onlay reinforcement to repair diaphragmatic defects from January 2005 to December 2014, were included in the study. Mesh covering alone was used in 47 patients and mesh with suturing was used in 16 patients. Patient demographics, Child-Pugh class, and model for end-stage liver disease (MELD) score were evaluated to predict morbidity and mortality.


Sponsor: National Taiwan University Hospital

Current Primary Outcome:

  • one-month mortality [ Time Frame: one month ]
    one-month mortality after thoracoscopic mesh repair
  • three-month mortality [ Time Frame: three month ]
    three-month mortality after thoracoscopic mesh repair


Original Primary Outcome: Same as current

Current Secondary Outcome: recurrence of hepatic hydrothorax [ Time Frame: 20.5 months ]

recurrence of hepatic hydrothorax after thoracoscopic mesh repair


Original Secondary Outcome: Same as current

Information By: National Taiwan University Hospital

Dates:
Date Received: July 21, 2015
Date Started: January 2005
Date Completion:
Last Updated: July 27, 2015
Last Verified: July 2015