Clinical Trial: The Impact of Ureteral Stents on Peristalsis

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Observational

Official Title: The Impact of Ureteral Stents on Peristalsis

Brief Summary: The purpose of the study is to investigate the impact of ureteral stents on the functioning of ureteral peristalsis (normal contractions in the ureteral organ muscle).

Detailed Summary: Ureteral stents are commonly used in the field of urology to maintain urinary drainage and are inserted into ureters of patients who suffer from kidney stones, urinary tract infections or cancer. Usually the muscle cells of the ureter contract in a coordinated fashion (peristalsis) in order to provide urinary flow from the kidney into the bladder. By inserting a stent these contractions are disrupted, eventually resulting in a loss of peristalsis. This phenomena is accompanied by swelling of the kidney and pain, which are well-known negative side effects of stents. To avoid stent-related morbidity and improve patients care this issue needs to be investigated further. A first step is to analyse the impact of stents on peristalsis and to possibly bring these results into context with hypothesised molecular mechanisms involved in peristalsis.
Sponsor: University of British Columbia

Current Primary Outcome: Effect of stent on ureteral peristalsis in stented ureter [ Time Frame: before and after stent insertion (approximately 30 minutes) ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Effect of stent on ureteral peristalsis in non-stented ureter [ Time Frame: 30 minutes (pre and post stenting) ]

Original Secondary Outcome: Same as current

Information By: University of British Columbia

Dates:
Date Received: November 29, 2012
Date Started: December 2012
Date Completion: December 2014
Last Updated: February 24, 2015
Last Verified: February 2015